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Myasthenia gravis (MG) is an autoimmune neuromuscular disorder characterized by fluctuating motor weakness involving ocular, bulbar, limb, and/or respiratory muscles. The weakness is due to an antibody-mediated, immunologic attack directed at proteins in the postsynaptic membrane of the neuromuscular junction (acetylcholine receptors or ... UpToDate is a trusted online resource that provides reliable and current information on various medical topics. Whether you are a physician, a patient, or a student, you can sign in with your email, username, or organization account to access UpToDate's evidence-based answers to your clinical questions. UpToDate personal subscriptions support physicians with evidence-based clinical recommendations. With so much change in the world of patient care, it is clear that access to continuously updated and reliable data is critical for both provider and patient satisfaction. UpToDate® connects you to the most current medical research and findings ...Neurofibromatosis type 1 (NF1), previously known as von Recklinghausen disease, is the most common type. The hallmarks of NF1 are the multiple café-au-lait macules and associated cutaneous neurofibromas. The condition is called segmental NF1 when clinical features are limited to one area of the body due to somatic mosaicism of a …

If your organization permits Single Sign-On (SSO) for UpToDate, you may use your email address here. If not, please enter your Username. Close Subscribe. Subscribe. UpToDate offers a number of subscriptions and add-on products, allowing you to have the most up-to-date information and improve patient care. About Us ... For over 30 years, clinicians around the world have trusted the evidence-based content in the UpToDate® clinical decision support (CDS) system to help make crucial care decisions when it matters most. Founded by clinicians for clinicians, and backed by an expert editorial team in over 25 specialties, UpToDate provides the latest medical ... INTRODUCTION. The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a disorder of impaired water excretion caused by the inability to suppress the secretion of antidiuretic hormone (ADH) [].If water intake exceeds the reduced urine output, the ensuing water retention leads to the development of hyponatremia.

This topic will focus on the treatment of hypernatremia induced by water loss, which is the most common cause. The treatment of hypernatremia in patients with impaired thirst, with or without arginine vasopressin disorders, and with primary sodium overload will also be reviewed. The causes and evaluation of patients with hypernatremia and the ...

Patient level information — UpToDate offers two types of patient education materials. The Basics — The Basics patient education pieces answer the four or five key questions a patient might have about a given condition. These articles are best for patients who want a general overview and who prefer short, easy-to-read materials.UpToDateFor over 30 years, clinicians around the world have trusted the evidence-based content in the UpToDate® clinical decision support (CDS) system to help make crucial care decisions when it matters most. Founded by clinicians for clinicians, and backed by an expert editorial team in over 25 specialties, UpToDate provides the latest medical ...Vitamin D decreases bone loss and lowers the risk of fracture, especially in older adults. Along with calcium, vitamin D also helps to prevent and treat osteoporosis. Adequate vitamin D is needed for efficient calcium absorption. Vitamin D is normally made in the skin after exposure to sunlight. (See "Patient education: Vitamin D deficiency ...

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Vitamin D decreases bone loss and lowers the risk of fracture, especially in older adults. Along with calcium, vitamin D also helps to prevent and treat osteoporosis. Adequate vitamin D is needed for efficient calcium absorption. Vitamin D is normally made in the skin after exposure to sunlight. (See "Patient education: Vitamin D deficiency ...

Sign in with Microsoft. Sign in with Open Athens. Sign in Another Way. If your organization permits Single Sign-On (SSO) for UpToDate, you may use your email address here. If …For over 30 years, clinicians around the world have trusted the evidence-based content in the UpToDate® clinical decision support (CDS) system to help make crucial care decisions when it matters most. Founded by clinicians for clinicians, and backed by an expert editorial team in over 25 specialties, UpToDate provides the latest medical ...Licensed to: UpToDate Marketing Professional Support Tag : [0502 - 157.55.39.49 - 01006D6174 - PR14 - UPT - 20240515-01:49:19UTC] - SM - MD - LG - XL LoadingUpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, Nephrology and Hypertension, Neurology, Obstetrics, Gynecology, and Women ...Although hypokalemia can be transiently induced by the entry of potassium into the cells, most cases result from unreplenished gastrointestinal or urinary losses due, for example, to vomiting, diarrhea, or diuretic therapy [ 1-3 ]. (See "Causes of hypokalemia in adults" .) Potassium replacement is primarily indicated when hypokalemia is due to ...

Cellulitis — The most common symptom of cellulitis is dull pain or tenderness in the area of skin involvement. Other cellulitis symptoms can include swelling, warmth, and redness in a distinct area of skin. These symptoms commonly worsen, and the redness may expand over the course of hours to days. The onset of cellulitis may be …Generalized anxiety disorder (GAD) is characterized by excessive worry and anxiety that are difficult to control, cause significant distress and impairment, and occur on more days than not for at least six months [ 1 ]. GAD is a relatively common disorder, most often with an adult onset and chronic course [ 2-6 ].UpToDate is an online platform that offers evidence-based clinical information and decision support for health care professionals and patients. To use UpToDate, you need to create an account or log in with your credentials.In some cases, heart failure can be mild and cause minor symptoms that are only evident with physical activity. Other times it can be severe (causing symptoms at rest) or even life-threatening. The most common symptoms of heart failure are shortness of breath, fatigue, leg swelling, and other signs of fluid retention.Oct 25, 2023 · A table summarizing the emergency management of acute hyponatremia in adults is provided ( table 1 ). An alternative approach, recommended in by European organizations, is to treat with two 150 mL bolus infusions of 3 percent saline, each given over 20 minutes, measuring the serum sodium between infusions [ 28 ]. PARENTERAL DRUGS. A variety of parenteral and oral antihypertensive drugs are available for use in these patients ( table 1) [ 1-7 ]. Few studies have compared these agents with one another, and all are tolerated reasonably well [ 8,9 ]. Thus, the drug of choice is often dictated by the type of hypertensive emergency and the local hospital ...Feb 12, 2024 · Although hypokalemia can be transiently induced by the entry of potassium into the cells, most cases result from unreplenished gastrointestinal or urinary losses due, for example, to vomiting, diarrhea, or diuretic therapy [ 1-3 ]. (See "Causes of hypokalemia in adults" .) Potassium replacement is primarily indicated when hypokalemia is due to ...

Peripheral artery disease (PAD), specifically atherosclerotic disease leading to peripheral artery obstruction, may be silent or present with a variety of symptoms and signs indicative of extremity ischemia. The clinical manifestations of arterial insufficiency (regardless of etiology) are due to a lack of blood flow to the musculature relative ...

Disclaimer: This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or …INTRODUCTION. Appendicitis, an inflammation of the vestigial vermiform appendix, is one of the most common causes of the acute abdomen and one of the most frequent indications for an emergency abdominal surgical procedure worldwide [ 1,2 ]. The clinical manifestations and differential diagnosis of appendicitis in adults will be reviewed here.The clinical presentation of adrenal insufficiency is variable, depending on whether the onset is acute, leading to adrenal crisis, or chronic, with symptoms that are insidious and vague. The diagnosis of adrenal insufficiency depends upon a critical level of clinical suspicion. Measurements of serum cortisol within three hours after wakening ...General symptoms — Thyroid hormone normally stimulates the metabolism, and most of the symptoms of hypothyroidism reflect slowing of metabolic processes. General symptoms may include fatigue, sluggishness, slight weight gain, and intolerance of cold temperatures. Skin — Hypothyroidism can decrease sweating.In-application and email messages will remind you to log in to UpToDate from your organization's network to re-verify your affiliation. If you are no longer affiliated with the providing institution: You can still access UpToDate if you are no longer affiliated with your institution by purchasing an individual subscription. Click here to subscribe.UpToDate, the evidence-based clinical decision support resource from Wolters Kluwer, is trusted at the point of care by clinicians worldwide.Mar 8, 2024 · Beta-lactamases are enzymes that open the beta-lactam ring, inactivating the antibiotic. The first plasmid-mediated beta-lactamase in gram-negative bacteria was discovered in Greece in the 1960s. It was named TEM after the patient from whom it was isolated (Temoniera) [ 2 ]. Subsequently, a closely related enzyme was discovered and named TEM-2.

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American Association of Nurse Practitioners (AANP) UpToDate is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 051212. For each hour of participation with the UpToDate program, NPs can claim 1.0 contact hour.Gabapentin is a medication used to treat nerve pain, seizures, and other conditions. Learn about its benefits, side effects, interactions, and how to use it safely from UpToDate, a trusted source of evidence-based medical information.Medicine Matters Sharing successes, challenges and daily happenings in the Department of Medicine Nadia Hansel, MD, MPH, is the interim director of the Department of Medicine in th...Other manifestations include lower abdominal pain and cramping, low-grade fever, nausea, and anorexia [ 2,5 ]. Diarrhea may be associated with mucus or occult blood, but melena or hematochezia are rare. Fever is associated with CDI in about 15 percent of cases; temperature >38.5°C may occur in the setting of nonsevere or severe CDI.Nov 7, 2023 · Polycystic ovary syndrome (PCOS) is a condition that causes irregular menstrual periods, symptoms of excess androgens (acne, hirsutism, and scalp hair loss), and ovaries that appear "polycystic" on pelvic ultrasound. The condition occurs in approximately 5 to 10 percent of females. Many females with PCOS are overweight or obese, and they are at ... Disclaimer: This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or …For over 30 years, clinicians around the world have trusted the evidence-based content in the UpToDate® clinical decision support (CDS) system to help make crucial care decisions when it matters most. Founded by clinicians for clinicians, and backed by an expert editorial team in over 25 specialties, UpToDate provides the latest medical ...UpToDate: Trusted, evidence-based solutions for modern healthcare. Dedicated to continuously innovating to meet the needs of the rapidly changing medical landscape, the UpToDate® suite offers clinical, drug, patient and member content to support health professionals wherever care takes place. Subscribe To UpToDate.Disclaimer: This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options.Management of insomnia requires a stepwise approach, beginning with attempts to eliminate, or at least minimize, the multiple contributing factors and comorbid illnesses that can interfere with optimal sleep. Insomnia often responds only partially to treatment of sleep-impairing influences, however, and many patients require treatment …

Nonsteroidal antiinflammatory drugs (NSAIDs) are medications used to relieve pain and to reduce inflammation. They are some of the most commonly used medications in adults. A variety of NSAIDs are available, including at least 20 in the United States and more elsewhere. Many are available as pills that can be purchased without a …The clinical features of KD reflect widespread inflammation of primarily medium-sized muscular arteries. Diagnosis is based upon evidence of systemic inflammation (eg, fever) in association with signs of mucocutaneous inflammation. The characteristic bilateral nonexudative conjunctivitis, erythema of the lips and oral mucosa, …Dissolved CO 2 + H 2 O ↔ H 2 CO 3 ↔ HCO 3- + H +. The ratio between these reactants can be expressed by the Henderson-Hasselbalch equation. By convention, the pKa of 6.10 is used when the denominator is the concentration of dissolved CO 2, and this is proportional to the pCO 2 (the actual concentration of the acid H 2 CO 3 is very …Nov 7, 2023 · Polycystic ovary syndrome (PCOS) is a condition that causes irregular menstrual periods, symptoms of excess androgens (acne, hirsutism, and scalp hair loss), and ovaries that appear "polycystic" on pelvic ultrasound. The condition occurs in approximately 5 to 10 percent of females. Many females with PCOS are overweight or obese, and they are at ... Instagram:https://instagram. dipole calculator Patient level information — UpToDate offers two types of patient education materials. The Basics — The Basics patient education pieces answer the four or five key questions a patient might have about a given condition. These articles are best for patients who want a general overview and who prefer short, easy-to-read materials. scrath pay UpToDate is a trusted online resource that provides reliable and current information on various medical topics. Whether you are a physician, a patient, or a student, you can sign in with your email, username, or organization account to access UpToDate's evidence-based answers to your clinical questions. phx to msp flights Dec 11, 2023 · Patient level information — UpToDate offers two types of patient education materials. The Basics — The Basics patient education pieces answer the four or five key questions a patient might have about a given condition. These articles are best for patients who want a general overview and who prefer short, easy-to-read materials. accurint for law enforcement The clinical presentation of adrenal insufficiency is variable, depending on whether the onset is acute, leading to adrenal crisis, or chronic, with symptoms that are insidious and vague. The diagnosis of adrenal insufficiency depends upon a critical level of clinical suspicion. Measurements of serum cortisol within three hours after wakening ... el paso texas to houston Jul 29, 2021 · Disclaimer: This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. hotels com usa Smoking cessation is associated with clear health benefits. Cigarette smoking is the leading preventable cause of death in the United States and worldwide. Tobacco use increases the risk of many acute and chronic diseases, including cancers at many sites. Medications, including nicotine replacement, varenicline, and bupropion, … brussels to london Indices Commodities Currencies StocksJustin Bufkin of One Smile Closer shares how he started a photography business on the side. He shares tips on anyone can make money with photography. Part-Time Money® Make extra mo... what is relational database Learn how to address excessive tardiness and find some of the simplest solutions to tardiness in the workplace. Human Resources | How To WRITTEN BY: Charlette Beasley Published Nov...Indices Commodities Currencies Stocks amozon mini tv Oct 6, 2023 · PARENTERAL DRUGS. A variety of parenteral and oral antihypertensive drugs are available for use in these patients ( table 1) [ 1-7 ]. Few studies have compared these agents with one another, and all are tolerated reasonably well [ 8,9 ]. Thus, the drug of choice is often dictated by the type of hypertensive emergency and the local hospital ... find name The management of bowel obstruction depends upon the etiology, severity, and location of the obstruction. The goals of initial management are to relieve discomfort and restore normal fluid volume, acid-base balance, and electrolytes. Bowel compromise (ischemia, necrosis, or perforation) and a surgically correctable cause of SBO (eg ... lat and lon INTRODUCTION. —. Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide. The clinical presentation of CAP varies, ranging from mild pneumonia characterized by fever and productive cough to severe pneumonia characterized by respiratory distress and sepsis.Art, as we all know, is about following a set number of rules handed to you by another person. In the latest New York Magazine cover story, art critic Jerry Saltz lists 33 steps to...The preventive treatment of episodic migraine headache in adults is reviewed here. The clinical features and management of chronic migraine (defined as ≥15 headache days per month) are discussed separately. (See "Chronic migraine" .) Other aspects of migraine are reviewed elsewhere.